Breaking bad family ties: Pan-ERBB blockers inhibit KRAS driven lung tumorigenesis
نویسندگان
چکیده
منابع مشابه
Diet-Induced Unresolved ER Stress Hinders KRAS-Driven Lung Tumorigenesis
Dietary effects on tumor biology can be exploited to unravel cancer vulnerabilities. Here, we present surprising evidence for anti-proliferative action of high-calorie-diet (HCD) feeding on KRAS-driven lung tumors. Tumors of mice that commenced HCD feeding before tumor onset displayed defective unfolded protein response (UPR) and unresolved endoplasmic reticulum (ER) stress. Unresolved ER stres...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2018
ISSN: 2372-3556
DOI: 10.1080/23723556.2018.1513724